Johannes Roth Selected Research

Toll-Like Receptor 4

1/2020	The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis.
1/2019	Alarmins of the S100-Family in Juvenile Autoimmune and Auto-Inflammatory Diseases.
7/2015	Myeloid-related protein 14 promotes inflammation and injury in meningitis.
4/2015	Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model.
12/2014	Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions.
5/2014	Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout.
1/2013	High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling.
6/2012	The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis.
5/2011	S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4: implications for bone destruction in murine antigen-induced arthritis.
11/2010	S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis.

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Johannes Roth Research Topics

Disease

62	Inflammation (Inflammations) 10/2021 - 11/2002
26	Infections 01/2018 - 04/2004
22	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 09/2022 - 09/2003
21	Arthritis (Polyarthritis) 11/2022 - 06/2003
16	Neoplasms (Cancer) 01/2022 - 08/2005
13	Sepsis (Septicemia) 12/2020 - 10/2005
7	Rheumatoid Arthritis 12/2019 - 06/2003
6	Rheumatic Diseases (Rheumatism) 01/2019 - 07/2007
5	Osteoarthritis 09/2019 - 05/2012
5	Necrosis 01/2016 - 08/2005
4	Pneumonia (Pneumonitis) 11/2022 - 05/2007
4	Osteoporosis 11/2021 - 08/2007
4	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 09/2003
4	Vasculitis (Vasculitides) 10/2018 - 09/2004
4	Experimental Arthritis 01/2018 - 11/2010
4	Contact Dermatitis (Eczema, Contact) 01/2018 - 03/2007
4	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2016 - 11/2005
4	Shock 04/2015 - 09/2007
4	Hypersensitivity (Allergy) 08/2014 - 03/2007
4	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 12/2007 - 04/2003
3	Breast Neoplasms (Breast Cancer) 01/2021 - 11/2008
3	Septic Shock (Toxic Shock Syndrome) 01/2021 - 12/2014
3	Peritonitis 01/2021 - 12/2009
3	Psoriatic Arthritis 01/2021 - 06/2003
3	Neoplasm Metastasis (Metastasis) 12/2020 - 01/2017
3	Synovitis 01/2020 - 05/2005
3	Pain (Aches) 01/2020 - 01/2014
3	Wounds and Injuries (Trauma) 01/2018 - 10/2012
3	Granuloma 01/2018 - 06/2007
3	Acute Lung Injury 01/2017 - 05/2007
3	Joint Diseases (Joint Disease) 10/2016 - 12/2005
3	Human Influenza (Influenza) 01/2014 - 10/2009
3	Cryopyrin-Associated Periodic Syndromes 12/2011 - 12/2008
3	Spondylarthropathies 12/2005 - 06/2003
2	Urinary Tract Infections (Urinary Tract Infection) 01/2022 - 09/2013
2	Tonsillitis 09/2021 - 06/2021
2	Bacterial Infections (Bacterial Infection) 06/2021 - 01/2018
2	Diabetes Mellitus 01/2021 - 12/2015
2	Cystic Fibrosis (Mucoviscidosis) 01/2021 - 01/2020
2	Peritonsillar Abscess 01/2021 - 01/2017
2	Neonatal Sepsis 12/2020 - 10/2005
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2020 - 12/2015
2	Dermatomyositis (Dermatopolymyositis) 01/2020 - 09/2013
2	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2020 - 09/2013
2	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2019 - 09/2009
2	Bone Resorption 01/2019 - 05/2011

Drug/Important Bio-Agent (IBA)

46	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2003
27	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2004
26	AlarminsIBA 01/2021 - 09/2009
18	CytokinesIBA 11/2022 - 10/2009
15	S100A12 ProteinIBA 12/2015 - 04/2003
14	Toll-Like Receptor 4IBA 01/2020 - 09/2007
13	Leukocyte L1 Antigen Complex (Calgranulin)IBA 01/2021 - 11/2002
13	S100 Proteins (S 100 Protein)IBA 12/2020 - 06/2003
10	LigandsIBA 05/2014 - 12/2007
8	GlucocorticoidsIBA 11/2021 - 01/2012
6	Methotrexate (Mexate)FDA LinkGeneric 09/2022 - 06/2003
6	Biological ProductsIBA 12/2020 - 01/2005
6	CalciumIBA 01/2019 - 06/2004
6	AntigensIBA 01/2018 - 06/2003
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2013 - 05/2005
5	Interleukin-6 (Interleukin 6)IBA 01/2021 - 10/2005
5	Interleukin-1 (Interleukin 1)IBA 01/2021 - 01/2010
5	EndotoxinsIBA 04/2015 - 09/2007
5	Receptor for Advanced Glycation End ProductsIBA 01/2015 - 04/2003
4	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 10/2010
4	C-Reactive ProteinIBA 01/2021 - 10/2005
4	InterleukinsIBA 01/2021 - 12/2011
4	Pattern Recognition ReceptorsIBA 01/2019 - 10/2005
4	ChemokinesIBA 04/2014 - 01/2013
4	Matrix Metalloproteinases (MMPs)IBA 08/2011 - 11/2003
3	tocilizumab (atlizumab)FDA Link 10/2021 - 04/2014
3	Messenger RNA (mRNA)IBA 12/2020 - 11/2005
3	Interleukin-17 (Interleukin 17)IBA 01/2020 - 06/2010
3	AutoantibodiesIBA 01/2020 - 09/2005
3	Peptides (Polypeptides)IBA 01/2018 - 06/2014
3	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2017 - 07/2007
3	Interleukin-8 (Interleukin 8)IBA 12/2015 - 10/2005
3	Calcium-Binding ProteinsIBA 01/2015 - 04/2003
3	EnzymesIBA 05/2014 - 12/2007
3	LipopolysaccharidesIBA 08/2013 - 10/2009
2	Insulin (Novolin)FDA Link 01/2022 - 02/2017
2	SteroidsIBA 11/2021 - 04/2015
2	Interleukin-18 (Interleukin 18)IBA 06/2021 - 01/2020
2	Vitamin D FDA LinkGeneric 01/2021 - 01/2012
2	Rheumatoid FactorIBA 01/2021 - 01/2016
2	paquinimodIBA 01/2021 - 07/2015
2	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2021 - 10/2016
2	ProteomeIBA 12/2020 - 12/2015
2	Peptide Hydrolases (Proteases)FDA Link 01/2020 - 01/2018
2	Antirheumatic Agents (DMARD)IBA 12/2019 - 01/2016
2	Irritants (Vesicants)IBA 01/2018 - 01/2018
2	Adrenal Cortex Hormones (Corticosteroids)IBA 08/2017 - 08/2007
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2017 - 10/2005

Therapy/Procedure

22	Therapeutics 01/2021 - 08/2005
2	Operative Surgical Procedures 09/2021 - 01/2018
2	Tonsillectomy 09/2021 - 06/2021
2	Critical Care (Surgical Intensive Care) 01/2021 - 01/2021
2	Transplantation 04/2019 - 01/2004
2	Drug Therapy (Chemotherapy) 01/2018 - 01/2018